منابع مشابه
Some new biosynthetic penicillins.
In our laboratories some 200 compounds, including phenylacetic acid derivatives, have been studied as possible precursors for new penicillins, and several of these appeared to give rise to new penicillins. In this report, five new penicillins, four of which were obtained in crystalline form, are described and their production, isolation, and characterization discussed. The methods employed in o...
متن کاملBiosynthesis of penicillins; new crystalline biosynthetic penicillins.
Paper III (1) in this series describes several tests which were found to be useful in determining whether a given compound is utilized by the mold in penicillin formation. To provide proof of the incorporation of various acyl groups into the penicillin molecule and to be able to determine the chemical characteristics and biological properties of the various penicillins, isolation and crystalliz...
متن کاملSome factors influencing the production of certain biosynthetic penicillins.
Basic media. (a) Natural. A medium containing 4 per cent corn steep solids, 4 per cent lactose, 1.5 per cent Cerelosel (92 per cent glucose) and 0.0044 per cent ZnSO4-7H20 was prepared in 95 per cent of the final volume. After adjustment to pH 5.6 to 5.8, it was sterilized by autoclaving. A suspension (20 per cent) of calcium carbonate was autoclaved separately. The calcium carbonate suspension...
متن کاملThe New Penicillins in Endocarditis.
FEW infections can kill a human being as rapidly as acute staphylococcal endocarditis in its most fulminant form. Infections caused by penicillinase producing staphylococci have been particularly difficult to manage. Successful treatment has been 'accomplished by combinations of antibiotics, by vancomycin, and even by huge doses of penicillin G. Still, the problem of therapy remains formidable....
متن کاملAntagonism of the antibacterial action of some penicillins by other penicillins and cephalosporins.
There are many examples of two penicillins acting synergistically, usually by one competitively inhibiting beta-lactamase, thus protecting the other from inactivation. There are few reports on penicillins antagonizing each other. Eight strains of three genera (Proteus, Escherichia, Pseudomonas) isolated at Boston City Hospital or Institut Pasteur, Paris, showed antagonism of carbenicillin or am...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1951
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)44862-4